HomePeptide dosagesPinealon
Pinealon dosage: chart, reported range and vial math
There is no established dose of Pinealon. The one published human dose is 100 mcg by mouth twice a day for two weeks, from a small Russian study. No published study injected it in people; reports of 100 to 300 mcg a day for 5 to 10 days are not a label dose. It is not approved in the US or Canada.
Pinealon dosage chart
Reported range, not a label dosePick your vial size. Each row shows the dose in milligrams or micrograms, the volume to draw and the mark on a U-100 syringe.
| Dose | Volume | Syringe units |
|---|---|---|
| 100 mcg | 0.01 mL | 1 units Too small to read well |
| 200 mcg | 0.02 mL | 2 units Too small to read well |
| 300 mcg | 0.03 mL | 3 units Too small to read well |
Source Reported range, not a label dose. Reports describe 100 to 300 mcg a day for 5 to 10 days, once or twice a year. The one published human dose is 100 mcg by mouth twice a day for two weeks. No published study injected it in people. Vial math is arithmetic.
Which syringe fits each dose
For the 20 mg vial at 10 mg/mL.
| Dose | Volume | Units | 0.3 mL syringe | 0.5 mL syringe | 1 mL syringe |
|---|---|---|---|---|---|
| 100 mcg | 0.01 mL | 1 units | Yes | Yes | Yes |
| 200 mcg | 0.02 mL | 2 units | Yes | Yes | Yes |
| 300 mcg | 0.03 mL | 3 units | Yes | Yes | Yes |
How long a vial lasts
Whole doses in one vial. The row for the size picked above is marked.
| Vial | 100 mcg | 200 mcg | 300 mcg |
|---|---|---|---|
| 20 mg vial | 200 doses | 100 doses | 66 doses |
How to mix a Pinealon vial
These steps are for the 20 mg vial picked in the chart. Change the size there and the amounts here change with it.
- Wash your hands. Wipe the stopper of the peptide vial and the water vial with an alcohol swab.
- Draw 2 mL of bacteriostatic water into a syringe.
- Push the needle through the stopper of the peptide vial and let the water run slowly down the glass, not straight onto the powder.
- Swirl the vial gently until the powder is gone. Do not shake it.
- Write the date and 10 mg/mL on the vial, then put it in the fridge.
| Vial | Bacteriostatic water | Concentration |
|---|---|---|
| 20 mg vial | 2 mL | 10 mg/mL |
What Pinealon is
Pinealon is a synthetic tripeptide, Glu-Asp-Arg (EDR), from the Khavinson group of short peptide bioregulators. It is studied for effects on nerve cells. [5]
Other names: EDR, EDR peptide, Glu-Asp-Arg, glutamyl-asparagin-arginine.
How it has been given to people: by mouth as capsules in the one human study with a stated dose; no human study of injection with a stated dose was found.
What to know before reading a dose
- Human data are thin: four small Russian studies, none described as placebo-controlled, published in one journal. Three of them tested Pinealon alongside a second peptide, Vesugen.
- The one human dose on record was taken by mouth, 100 mcg twice a day. No published study injected Pinealon in people, so injected doses in circulation have no trial behind them.
- The reported injected range is 5 to 25 times the daily amount used in that study, and by a different route.
- One human study found signs of reduced blood cell formation and pro-oxidant activity [2]. Its authors still recommended the peptide.
- The nerve cell and memory findings are from cell culture, rats and mice, and come mostly from the group that developed the peptide [5], [6], [7], [8].
- Not an approved medicine in the US or Canada as of the check date. Health Canada lists Pinealon among unauthorized injectable peptide drugs seized from an online seller [13].
Doses on record for Pinealon
Every dose below was given in a human study or printed on an approved label, and each links to its source. Doses set by body weight are left that way.
| From | Where it was used | Dose | How often | For how long | Source |
|---|---|---|---|---|---|
| Human study | Russian study of railway locomotive crews (design, phase and number of people not stated in the abstract); capsules by mouth, not injected. The abstract writes the unit as mkg, meaning micrograms. | 100 mcg per capsule | one capsule twice a day | two weeks | [1] |
What the evidence shows
Each finding is tagged by the kind of study it comes from. Human trials are listed first.
Small human study
In railway locomotive crews, two weeks of capsules was reported to improve biological age measures. The abstract gives no numbers, no group sizes and no placebo group. [1]
Small human study
In 32 people aged 41 to 83 with several chronic illnesses, Pinealon and a second peptide, Vesugen, were reported to slow aging measures; Vesugen did better. The abstract gives no dose. [2]
Small human study
In a comparison of anti-aging methods in 110 people, the largest change in biological age measures came when Pinealon and Vesugen were used together, so the result cannot be credited to Pinealon alone. [3]
Small human study
In a study of long-distance truck drivers, peptide use was reported to improve measures of mental strain, with the best result again from Pinealon combined with Vesugen. [4]
Animal study
Given to pregnant rats with raised homocysteine, it improved learning and spatial orientation in their offspring. [6]
Animal study
In a mouse model of Alzheimer's disease, the EDR peptide prevented loss of dendritic spines. [8]
Lab study
In cultured cells under oxidative stress, Pinealon limited the build-up of reactive oxygen species. [5]
Lab study
In neurons made in the lab from skin cells of elderly donors, the EDR peptide reduced oxidative DNA damage. [9]
Side effects and warnings
Reported in human studies or on a label:
- The study in 32 people found a fall in a blood stem cell marker, which the authors read as inhibition of blood cell formation. [2]
- The same study found pro-oxidant activity, the opposite of the antioxidant effect seen in cell culture. [2]
- The comparison in 110 people rated the peptide preparations and massage as the safest of the methods tested, judged by blood tests and clinical condition. No independent human safety study was found. [3]
Pinealon has no approved label in the US or Canada for this use, so there is no official list of who should not use it, no interaction list and no missed-dose rule.
Storage
Keep an unmixed vial the way its label says. Once it is mixed, keep it in the fridge, do not freeze it, and write the mixing date on the vial.
Pinealon dosage questions
How many units is 100 mcg of Pinealon from a 20 mg vial?
Mixed with 2 mL of bacteriostatic water, a 20 mg vial is 10 mg/mL. 100 mcg is 0.01 mL, which is 1 units on a U-100 syringe.
How much water goes in a 20 mg Pinealon vial?
2 mL gives 10 mg/mL. At that strength the doses in the chart sit at 1, 2, 3 units on a U-100 syringe.
How many doses are in a 20 mg vial?
Whole doses in one vial: 200 at 100 mcg, 100 at 200 mcg, 66 at 300 mcg.
Is Pinealon approved in the US?
Not FDA approved. No Pinealon product or label was found in Drugs@FDA.
Is Pinealon authorized in Canada?
No Pinealon product is in Health Canada's Drug Product Database, and Health Canada lists Pinealon among unauthorized injectable peptide drugs seized from an online seller.
What human dosing data is there for Pinealon?
Human data are thin: four small Russian studies, none described as placebo-controlled, published in one journal. Three of them tested Pinealon alongside a second peptide, Vesugen.
Sources
Each one was opened on 10 Oct 2026 and matched to the line it supports.
- Nazimko VA et al. [Analysis of some parameters of biological age and adaptation possibilities of workers of locomotive brigades]. Adv Gerontol 2012. PubMed 22708445.
- Meshchaninov VN et al. [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION]. Adv Gerontol 2015. PubMed 26390612.
- Myakotnykh VS et al. [Comparative analysis of different methods of geroprotective]. Adv Gerontol 2016. PubMed 28539017.
- Bashkireva AS et al. [The peptide correction of neurotic disorders among professional truck-drivers]. Adv Gerontol 2012. PubMed 23734521.
- Khavinson V et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res 2011. PubMed 21978084.
- Arutjunyan A et al. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med 2012. PubMed 22567179.
- Khavinson V et al. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease. Molecules 2020. PubMed 33396470.
- Khavinson V et al. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel) 2021. PubMed 34071923.
- Kraskovskaya N et al. Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes. Int J Mol Sci 2024. PubMed 39518916.
- US Food and Drug Administration Drugs@FDA and drug label searches via openFDA for pinealon (no match) 2026. api.fda.gov.
- Health Canada Health Canada Drug Product Database, active ingredient searches: pinealon and glu-asp-arg (0 records) 2026. health-products.canada.ca.
- US Food and Drug Administration Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks 2026. fda.gov.
- Health Canada Unauthorized injectable peptide drugs seized and sold by Canada Peptide may pose serious health risks 2025. recalls-rappels.canada.ca.
- World Anti-Doping Agency The Prohibited List 2026. wada-ama.org.
Looked for and not found
- No human study of Pinealon given by injection with a stated dose. The only human dose found is 100 mcg by mouth twice a day for two weeks [1].
- The other three human papers [2], [3], [4] give no dose in their abstracts. All four are in Russian and only their English abstracts were read.
- No randomized, placebo-controlled trial. None of the human abstracts describes a placebo group or blinding.
- The study behind the line that the peptide improves memory in elderly patients, which appears in a 2020 review by its originators [7].
- No human half-life or other pharmacokinetic figure.
- No trial registered on ClinicalTrials.gov: a search for pinealon as the intervention returned no studies.
- No approved label in the US or Canadian sources searched, so no official dose, contraindications or storage instructions.
- Not named on the WADA Prohibited List (page checked 2026-10-11, [14]). The list has an open class, S0, for substances with no current approval by any governmental health authority; whether it applies to this compound was not determined here.
Change log
10 Oct 2026Page published. 14 sources checked. Vial math added for the 20 mg vial.
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