Skip to main content Skip to main content

Peptide Dosages | DosageFacts

Peptide dosage reference for the US and Canada
DOSAGEFACTS

HomePeptide dosages5-Amino-1MQ

5-Amino-1MQ dosage: what is known

There is no human dose for 5-Amino-1MQ. Every published result comes from cells, mice or rats, and no clinical trial is registered. Sellers suggest 50 to 150 mg a day by mouth, but nothing in people backs that number. It is a small molecule, not a peptide, and it is not approved.

Last checked 10 Oct 2026Sources 11 checkedChange log

Legal status

US Not approved

Canada Not authorized

Checked 10 Oct 2026What is 5-Amino-1MQ?

5-Amino-1MQ dose

No human dose

No human dose has been set for 5-Amino-1MQ and no human study has been published. Reports describe 50 to 150 mg a day by mouth, which is not an injection dose, so there is no syringe table here.

What people report using

Peer reports. Not medical or scientific advice.

HowAmount people reportPattern people report
By mouth50 to 150 mg a day4 to 8 weeks, then a break

These are amounts users describe online, taken from Google AI Overview for the search 'what are known 5-amino-1mq protocols' on 11 Oct 2026. No human study has tested them, no doctor or regulator has checked them, and they are not a recommendation. They are here so you know what is being passed around.

What 5-Amino-1MQ is

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule that blocks the enzyme nicotinamide N-methyltransferase (NNMT). It is not a peptide. Everything published on it comes from cells, mice and rats. [2]

Other names: 5-amino-1-methylquinolinium, 5A1MQ, 5-AMQ, NNMTi.

How it has been given to people: no human use on record.

What to know before reading a dose

  • No human data. Every result on record is from cells, mice or rats, so no dose for people has been tested.
  • It is a small molecule, not a peptide, even though Health Canada's seizure list groups a product of this name with injectable peptide drugs [10].
  • Not approved in the US or Canada. Health Canada has seized a product sold under this name as an unauthorized drug [10].
  • The six studies cited here share authors from one research group.
  • The mouse dose in the first study was 20 mg per kg three times a day. That is an animal dose and cannot be read across as a dose for a person.

What the evidence shows

Each finding is tagged by the kind of study it comes from. Human trials are listed first.

Animal study

In diet-induced obese mice, an NNMT inhibitor cut body weight and white fat and lowered total cholesterol. The full text names the compound as 5-amino-1MQ. [1]

Animal study

That mouse study injected 20 mg per kg under the skin three times a day for 11 days, with 9 mice per group. [1]

Animal study

The same mice ate as much as controls and showed no visible ill effects over the 11 days. [1]

Animal study

Given once a day for 28 days to obese mice, it limited weight and fat gain in a dose-dependent way and improved glucose tolerance and insulin sensitivity. [2]

Animal study

Added to a switch to a lean diet, it sped up weight and fat loss in obese mice compared with the diet switch alone. [3]

Animal study

In 24-month-old mice given 5 or 10 mg per kg after a muscle injury, muscle stem cell activity went up. [4]

Animal study

Aged sedentary mice treated from 22 to 24 months of age had about 40% greater grip strength than untreated sedentary mice. [5]

Animal study

In rats, 38.4% of a dose given by mouth reached the bloodstream. [6]

Lab study

In cultured fat cells, NNMT inhibitors raised NAD+ and suppressed fat formation. [1]

Side effects and warnings

No side effect data from human studies was found for 5-Amino-1MQ. That is a gap in the research, not a sign that it is safe.

5-Amino-1MQ has no approved label in the US or Canada for this use, so there is no official list of who should not use it, no interaction list and no missed-dose rule.

Storage

Keep an unmixed vial the way its label says. Once it is mixed, keep it in the fridge, do not freeze it, and write the mixing date on the vial.

5-Amino-1MQ dosage questions

Is 5-Amino-1MQ approved in the US?

Not FDA approved. Drugs@FDA has no application for it and no clinical trial is registered.

Is 5-Amino-1MQ authorized in Canada?

No product is in the Health Canada Drug Product Database. A product labelled 5-AMINO-IMQ was among unauthorized products Health Canada seized.

What human dosing data is there for 5-Amino-1MQ?

No human data. Every result on record is from cells, mice or rats, so no dose for people has been tested.

Sources

Each one was opened on 10 Oct 2026 and matched to the line it supports.

  1. Neelakantan H et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol 2018. PubMed 29155147.
  2. Babula JJ et al. Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction. Diabetes Obes Metab 2024. PubMed 39161060.
  3. Sampson CM et al. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. Sci Rep 2021. PubMed 33707534.
  4. Neelakantan H et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol 2019. PubMed 30753815.
  5. Dimet-Wiley AL et al. Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Sci Rep 2024. PubMed 38969654.
  6. Awosemo O et al. Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies. J Pharm Biomed Anal 2021. PubMed 34304009.
  7. ClinicalTrials.gov searches for 5-amino-1MQ, 5-amino-1-methylquinolinium and NNMT inhibitor (0 matching studies) clinicaltrials.gov.
  8. Drugs@FDA via openFDA: searches for 5-amino-1MQ and 5-amino-1-methylquinolinium (no match) api.fda.gov.
  9. Health Canada Drug Product Database: ingredient searches for 5-amino, amino-1 and methylquinolinium (no match) health-products.canada.ca.
  10. Health Canada public advisory: Unauthorized health products sold online and seized at Rize Fitness may pose serious health risks (2025-12-24) recalls-rappels.canada.ca.
  11. FDA: Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act (PDF, updated May 14, 2026) fda.gov.

Looked for and not found

  • Any human study. PubMed returned no clinical trial for the compound's names, and ClinicalTrials.gov returned no registered study [7].
  • A human dose, a human half-life, or human side effects. None exists in the sources found.
  • No approved label anywhere, so no official contraindications, interaction list, missed-dose rule or storage instructions.
  • The rat half-life is in the [6] abstract but is not quoted, because the abstract prints it with a plus-minus sign.
  • The percentage of weight lost in the 11-day mouse study is in the [1] full text but is not quoted, for the same reason.

Change log

10 Oct 2026Page published. 11 sources checked. No dose chart, because no human dose exists.

Related

Retatrutide dosageTirzepatide dosageSemaglutide dosageCagrilintide dosageAOD-9604 dosageWhat 5-Amino-1MQ isWeight loss and metabolicPeptide dosage chartDosage calculator

DosageFacts is an information site. It is not medical advice. Talk to a licensed professional before using any medication.